Background:

The first example of thermoreversible supramolecular double-network (DN) hydrogel via temperature triggered co-assembly of pentafluorobenzyl-diphenylalanine (PFB-FF) peptide and poly (ethylene glycol) polymer is discovered. The strategy is based on the idea that temperature triggered the co-assembly of peptide/PEG will enhance the stability of hydrogel due to the co-existence of noncovalent (e.g., π–π stacking, hydrogen bonding) compared with peptide or PEG alone. Compared to PFB-FF or PEG alone, the thermoreversible supramolecular PFB-FF/PEG DN hydrogel had much better mechanical strength, stability and biocompatibility. This work provides new insights into the design of the co-assembly of thermoreversible supramolecular DN hydrogel for biomaterials application.
The double-network (DN) hydrogel has excellent mechanical properties which originate from the combination of two networks with contrasting structures.[10] The double-network hydrogels with high mechanical strength have demonstrated their feasibility in many field applications such as artificial cartilage,[11] three-dimensional (3D) cell culture,[4] biosensor,[12] 3D/4D printing,[13] controller cell and drug release,[14] cornea repairing,[15] and tissue engineering.[16] Recently, Gong et al. discovered a DN gel which has great mechanical strength compared to single network (SN) polymeric hydrogel.[15, 17] DN hydrogels are generally prepared via a multi-step sequential free radical polymerization process.[15, 18] For example, poly(methacrylic acid) (PMAA) is used to form a rigid and brittle polymer as the first network.[17b] PMAA would be immersed into a precursor solution polyacrylamide (PAAm) containing a neutral second monomer and cross-linkers for the second polymerization. The reactant will react each other to form a loosely cross-linked, soft, and ductile, as the second network. However, this multi-step polymerization for DN gels still facing many challenges such as controlling the exact molar ratio and need a large amount of the second network for completely reacting with the first network.[19]

Pengalaman Riset:
CPPBT (Calon Perusahaan Pemula Berbasis Teknologi) 2018
World Class Professor Program 2018